Large language models (LLMs) have been shown to be able to perform new tasks based on a few demonstrations or natural language instructions. While these capabilities have led to widespread adoption, most LLMs are developed by resource-rich organizations and are frequently kept from the public. As a step towards democratizing this powerful technology, we present BLOOM, a 176B-parameter open-access language model designed and built thanks to a collaboration of hundreds of researchers. BLOOM is a decoder-only Transformer language model that was trained on the ROOTS corpus, a dataset comprising hundreds of sources in 46 natural and 13 programming languages (59 in total). We find that BLOOM achieves competitive performance on a wide variety of benchmarks, with stronger results after undergoing multitask prompted finetuning. To facilitate future research and applications using LLMs, we publicly release our models and code under the Responsible AI License.

SARS-COV-2是一种上呼吸系统的RNA病毒，截至2021年5月，在全球范围内引起超过300万人死亡，截至5月201日。迄今为止，SARS-COV-2突变对科学家造成重大挑战跟上疫苗开发和公共卫生措施的步伐。因此，鉴定来自患者的实验室样本分歧的有效方法非常有助于SARS-COV-2基因组学的文件。在这项研究中，我们提出了一种神经网络模型，可利用复发性和卷积单元直接参与尖峰蛋白的氨基酸序列并分类相应的片状。我们还将我们的模型的性能与来自蛋白质数据库预先培训的变压器（BERT）的双向编码器表示。我们的方法具有基于基于物种内分化的当前同源性提供了更加计算上的替代方案。

Although many studies have successfully applied transfer learning to medical image segmentation, very few of them have investigated the selection strategy when multiple source tasks are available for transfer. In this paper, we propose a prior knowledge guided and transferability based framework to select the best source tasks among a collection of brain image segmentation tasks, to improve the transfer learning performance on the given target task. The framework consists of modality analysis, RoI (region of interest) analysis, and transferability estimation, such that the source task selection can be refined step by step. Specifically, we adapt the state-of-the-art analytical transferability estimation metrics to medical image segmentation tasks and further show that their performance can be significantly boosted by filtering candidate source tasks based on modality and RoI characteristics. Our experiments on brain matter, brain tumor, and white matter hyperintensities segmentation datasets reveal that transferring from different tasks under the same modality is often more successful than transferring from the same task under different modalities. Furthermore, within the same modality, transferring from the source task that has stronger RoI shape similarity with the target task can significantly improve the final transfer performance. And such similarity can be captured using the Structural Similarity index in the label space.

Modern deep neural networks have achieved superhuman performance in tasks from image classification to game play. Surprisingly, these various complex systems with massive amounts of parameters exhibit the same remarkable structural properties in their last-layer features and classifiers across canonical datasets. This phenomenon is known as "Neural Collapse," and it was discovered empirically by Papyan et al. \cite{Papyan20}. Recent papers have theoretically shown the global solutions to the training network problem under a simplified "unconstrained feature model" exhibiting this phenomenon. We take a step further and prove the Neural Collapse occurrence for deep linear network for the popular mean squared error (MSE) and cross entropy (CE) loss. Furthermore, we extend our research to imbalanced data for MSE loss and present the first geometric analysis for Neural Collapse under this setting.

In this paper we derive a PAC-Bayesian-Like error bound for a class of stochastic dynamical systems with inputs, namely, for linear time-invariant stochastic state-space models (stochastic LTI systems for short). This class of systems is widely used in control engineering and econometrics, in particular, they represent a special case of recurrent neural networks. In this paper we 1) formalize the learning problem for stochastic LTI systems with inputs, 2) derive a PAC-Bayesian-Like error bound for such systems, 3) discuss various consequences of this error bound.

Denoising Diffusion Probabilistic Models (DDPMs) are emerging in text-to-speech (TTS) synthesis because of their strong capability of generating high-fidelity samples. However, their iterative refinement process in high-dimensional data space results in slow inference speed, which restricts their application in real-time systems. Previous works have explored speeding up by minimizing the number of inference steps but at the cost of sample quality. In this work, to improve the inference speed for DDPM-based TTS model while achieving high sample quality, we propose ResGrad, a lightweight diffusion model which learns to refine the output spectrogram of an existing TTS model (e.g., FastSpeech 2) by predicting the residual between the model output and the corresponding ground-truth speech. ResGrad has several advantages: 1) Compare with other acceleration methods for DDPM which need to synthesize speech from scratch, ResGrad reduces the complexity of task by changing the generation target from ground-truth mel-spectrogram to the residual, resulting into a more lightweight model and thus a smaller real-time factor. 2) ResGrad is employed in the inference process of the existing TTS model in a plug-and-play way, without re-training this model. We verify ResGrad on the single-speaker dataset LJSpeech and two more challenging datasets with multiple speakers (LibriTTS) and high sampling rate (VCTK). Experimental results show that in comparison with other speed-up methods of DDPMs: 1) ResGrad achieves better sample quality with the same inference speed measured by real-time factor; 2) with similar speech quality, ResGrad synthesizes speech faster than baseline methods by more than 10 times. Audio samples are available at https://resgrad1.github.io/.

As an important variant of entity alignment (EA), multi-modal entity alignment (MMEA) aims to discover identical entities across different knowledge graphs (KGs) with multiple modalities like images. However, current MMEA algorithms all adopt KG-level modality fusion strategies but ignore modality differences among individual entities, hurting the robustness to potential noise involved in modalities (e.g., unidentifiable images and relations). In this paper we present MEAformer, a multi-modal entity alignment transformer approach for meta modality hybrid, to dynamically predict the mutual correlation coefficients among modalities for instance-level feature fusion. A modal-aware hard entity replay strategy is also proposed for addressing vague entity details. Extensive experimental results show that our model not only achieves SOTA performance on multiple training scenarios including supervised, unsupervised, iterative, and low resource, but also has limited parameters, optimistic speed, and good interpretability. Our code will be available soon.

Deep learning has been widely used for protein engineering. However, it is limited by the lack of sufficient experimental data to train an accurate model for predicting the functional fitness of high-order mutants. Here, we develop SESNet, a supervised deep-learning model to predict the fitness for protein mutants by leveraging both sequence and structure information, and exploiting attention mechanism. Our model integrates local evolutionary context from homologous sequences, the global evolutionary context encoding rich semantic from the universal protein sequence space and the structure information accounting for the microenvironment around each residue in a protein. We show that SESNet outperforms state-of-the-art models for predicting the sequence-function relationship on 26 deep mutational scanning datasets. More importantly, we propose a data augmentation strategy by leveraging the data from unsupervised models to pre-train our model. After that, our model can achieve strikingly high accuracy in prediction of the fitness of protein mutants, especially for the higher order variants (> 4 mutation sites), when finetuned by using only a small number of experimental mutation data (<50). The strategy proposed is of great practical value as the required experimental effort, i.e., producing a few tens of experimental mutation data on a given protein, is generally affordable by an ordinary biochemical group and can be applied on almost any protein.

Deep neural networks (DNNs) are found to be vulnerable to adversarial attacks, and various methods have been proposed for the defense. Among these methods, adversarial training has been drawing increasing attention because of its simplicity and effectiveness. However, the performance of the adversarial training is greatly limited by the architectures of target DNNs, which often makes the resulting DNNs with poor accuracy and unsatisfactory robustness. To address this problem, we propose DSARA to automatically search for the neural architectures that are accurate and robust after adversarial training. In particular, we design a novel cell-based search space specially for adversarial training, which improves the accuracy and the robustness upper bound of the searched architectures by carefully designing the placement of the cells and the proportional relationship of the filter numbers. Then we propose a two-stage search strategy to search for both accurate and robust neural architectures. At the first stage, the architecture parameters are optimized to minimize the adversarial loss, which makes full use of the effectiveness of the adversarial training in enhancing the robustness. At the second stage, the architecture parameters are optimized to minimize both the natural loss and the adversarial loss utilizing the proposed multi-objective adversarial training method, so that the searched neural architectures are both accurate and robust. We evaluate the proposed algorithm under natural data and various adversarial attacks, which reveals the superiority of the proposed method in terms of both accurate and robust architectures. We also conclude that accurate and robust neural architectures tend to deploy very different structures near the input and the output, which has great practical significance on both hand-crafting and automatically designing of accurate and robust neural architectures.

People with diabetes are more likely to develop diabetic retinopathy (DR) than healthy people. However, DR is the leading cause of blindness. At present, the diagnosis of diabetic retinopathy mainly relies on the experienced clinician to recognize the fine features in color fundus images. This is a time-consuming task. Therefore, in this paper, to promote the development of UW-OCTA DR automatic detection, we propose a novel semi-supervised semantic segmentation method for UW-OCTA DR image grade assessment. This method, first, uses the MAE algorithm to perform semi-supervised pre-training on the UW-OCTA DR grade assessment dataset to mine the supervised information in the UW-OCTA images, thereby alleviating the need for labeled data. Secondly, to more fully mine the lesion features of each region in the UW-OCTA image, this paper constructs a cross-algorithm ensemble DR tissue segmentation algorithm by deploying three algorithms with different visual feature processing strategies. The algorithm contains three sub-algorithms, namely pre-trained MAE, ConvNeXt, and SegFormer. Based on the initials of these three sub-algorithms, the algorithm can be named MCS-DRNet. Finally, we use the MCS-DRNet algorithm as an inspector to check and revise the results of the preliminary evaluation of the DR grade evaluation algorithm. The experimental results show that the mean dice similarity coefficient of MCS-DRNet v1 and v2 are 0.5161 and 0.5544, respectively. The quadratic weighted kappa of the DR grading evaluation is 0.7559. Our code will be released soon.